Nicotinamide adenine dinucleotide (NAD\u207a) is a vital coenzyme in every cell in the body. It is centrally involved in processes such as mitochondrial energy production (ATP production), DNA repair, cellular regeneration and epigenetic regulation. NAD\u207a levels fall with increasing age and under stress from infections, oxidative stress or intensive sporting activity - with far-reaching consequences for health and quality of life.<\/p>\n
A low NAD\u207a status is not a harmless physiological finding of old age, but promotes the development of numerous chronic diseases. Age, viral reactivation, inflammation and oxidative stress are among the main causes of NAD\u207a loss. Restoring adequate NAD\u207a levels is therefore a central approach of modern longevity medicine.<\/p>\n
Vitamin B3 (niacin) already played a key role in the early phase of orthomolecular therapies. Abraham Hoffer, a pioneer of orthomolecular psychiatry, used it successfully to treat schizophrenic disorders. Today, vitamin B3 in the form of its modern derivatives such as nicotinamide riboside is experiencing a scientifically founded renaissance.<\/p>\n
Nicotinamide riboside (NR) is an innovative vitamin B3 derivative that can contribute particularly efficiently to increasing intracellular NAD\u207a levels. As a precursor, NR is converted into NAD\u207a in the liver and other tissues. This creates a synergistic effect: the combination of nicotinamide with ribose - a component of the ATP molecule - promotes mitochondrial function and energy supply. The renowned pharmacologist Uwe Gr\u00f6ber therefore describes NR as a \u201emaster regulator\u201c for NAD\u207a.<\/p>\n
1. cellular energy production<\/b>
\nNAD\u207a is essential for the redox reactions in the mitochondria and for ATP production as part of the respiratory chain. NADH and NAD\u207a form a redox pair that enables electron transfer - without this process, cellular energy deficits and exhaustion occur.<\/p>\n
2. activation of sirtuin longevity enzymes<\/b>
\nSirtuins (especially SIRT1) regulate ageing processes, DNA repair, metabolism and inflammatory processes. They are strictly NAD\u207a-dependent. An increased NAD\u207a level increases sirtuin activity and thus cellular resistance to ageing, stress and metabolic dysregulation.<\/p>\n
3. telomerase activation and telomere lengthening<\/b>
\nCurrent studies show: NAD\u207a promotes the activity of telomerase, an enzyme that slows down the shortening of telomeres (age-related \u201ewear and tear\u201c of chromosome ends). This is considered a cellular marker for healthy lifespan and longevity.<\/p>\n
4. neuroprotection and cognitive health<\/b>
\nNAD\u207a plays a central role in maintaining neuronal functions. It protects nerve cells from degeneration, particularly via SIRT1-mediated effects. In mouse models, NAD\u207a was able to significantly improve cognitive deficits in Alzheimer's disease. Preventive use therefore seems sensible.<\/p>\n
5. DNA repair mechanisms through PARPs<\/b>
\nNAD\u207a is an essential substrate for poly-ADP-ribose polymerases (PARPs), which recognize and repair DNA damage. Chronic NAD\u207a deficiency reduces this repair capacity and promotes degenerative and oncological diseases.<\/p>\n
6. modulation of CD38 and chronic inflammation<\/b>
\nCD38\/CD157 are NAD\u207a-consuming enzymes that are associated with ageing processes, tumor progression and immune modulation. Their excessive activity in aging and chronic stress accelerates NAD\u207a loss. Targeted regulation is the subject of current research.<\/p>\n
\nClinical applications of nicotinamide riboside<\/h3>\n
Targeted supplementation with nicotinamide riboside offers potential for:<\/p>\n
Nicotinamide riboside is a scientifically proven way of specifically increasing cellular NAD\u207a levels. The positive effects range from improved mitochondrial function and epigenetic regulation to preventive approaches for neurodegenerative diseases and ageing processes. NAD\u207a is not just an energy supplier - it is the key factor for cellular health, longevity and function-preserving ageing.<\/p>\n
Scientific sources:<\/b><\/p>\n Publications by Dr. med. Andreas Bernhardt:<\/b><\/p>\n About Dr. med. Andreas Bernhardt:<\/strong> Einf\u00fchrung: Warum NAD\u207a so essenziell ist Nicotinamid-Adenin-Dinukleotid (NAD\u207a) ist ein lebenswichtiges Coenzym in jeder K\u00f6rperzelle. Es ist zentral an Prozessen wie der mitochondrialen Energiegewinnung (ATP-Produktion), DNA-Reparatur, zellul\u00e4rer Regeneration und epigenetischer Regulation beteiligt. Mit zunehmendem Alter sowie unter Belastung durch Infektionen, oxidativen Stress oder intensive sportliche Aktivit\u00e4t sinkt der NAD\u207a-Spiegel \u2013 mit weitreichenden Konsequenzen f\u00fcr Gesundheit […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","_seopress_titles_title":"Warum Nicotinamid-Adenin-Dinukleotid (NAD\u207a) so essenziell ist","_seopress_titles_desc":"Nicotinamid-Adenin-Dinukleotid (NAD\u207a) ist ein lebenswichtiges Coenzym in K\u00f6rperzellen. Es ist zentral bei Prozessen wie der mitochondrialen Energiegewinnung.","_seopress_robots_index":"","footnotes":""},"categories":[1],"tags":[],"post_folder":[],"class_list":["post-6816","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www.biohormontherapie.ch\/en\/wp-json\/wp\/v2\/posts\/6816","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biohormontherapie.ch\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biohormontherapie.ch\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biohormontherapie.ch\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biohormontherapie.ch\/en\/wp-json\/wp\/v2\/comments?post=6816"}],"version-history":[{"count":3,"href":"https:\/\/www.biohormontherapie.ch\/en\/wp-json\/wp\/v2\/posts\/6816\/revisions"}],"predecessor-version":[{"id":8749,"href":"https:\/\/www.biohormontherapie.ch\/en\/wp-json\/wp\/v2\/posts\/6816\/revisions\/8749"}],"wp:attachment":[{"href":"https:\/\/www.biohormontherapie.ch\/en\/wp-json\/wp\/v2\/media?parent=6816"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biohormontherapie.ch\/en\/wp-json\/wp\/v2\/categories?post=6816"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biohormontherapie.ch\/en\/wp-json\/wp\/v2\/tags?post=6816"},{"taxonomy":"post_folder","embeddable":true,"href":"https:\/\/www.biohormontherapie.ch\/en\/wp-json\/wp\/v2\/post_folder?post=6816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
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\nDr. Bernhardt is a specialist in general internal medicine with an international Training in endocrinology and better aging<\/a>. He is a member of the Swiss Anti-Aging Society (SSAAMP) and the renowned Endocrine Society (Washington, D.C.). His focus is on bioidentical hormone therapy as part of a holistic longevity concept. As an expert on the German-speaking platform wechselweise.net<\/a> he is committed to raising awareness in the DACH region about hormonal changes in men and women during the menopause - with the aim of promoting health and quality of life in the long term.<\/p>","protected":false},"excerpt":{"rendered":"